John J. LaPres

John  J.  LaPres
  • Director
  • Professor
  • BioMolecular Sciences Graduate Studies
  • Biochemistry and Molecular Biology



John LaPres' research is focused on the PAS superfamily of proteins and their role in toxicity. Specifically, he is interested in the signaling of dioxins and PCBs through the aryl hydrocarbon receptor and the role cofactors play in this toxic pathway. His secondary interests lie in the role hypoxia inducible factors (HIFs) play in tumor growth, angiogenesis and metal induced toxicity and transformation. His laboratory is focusing on characterizing the gene expression profiles of various cell lines and tissues following treatment to environmentally important metals, including nickel, cadmium and chromium. This approach has given us extensive experience in the production, application and analysis of cDNA microarrays. Our toxicogenomic studies will focus on critically evaluating identified genes for their role in metal induced toxicity.


  • Dioxins
  • PCBs
  • Hypoxia inducible factors